مقالات پذیرفته شده در سومین کنگره بین المللی زیست پزشکی
Carbon-Based Nanomaterials in Tissue Engineering
Carbon-Based Nanomaterials in Tissue Engineering
Sara Tabatabaee,1Nafiseh baheiraei,2,*
1. Department of Bio-Computing, Faculty of Interdisciplinary Science and Technologies, Tarbiat Modares University 2. Tissue Engineering & Applied Cell Sciences Division, Department of Hematology, Faculty of Medical science, Tarbiat Modares University
Introduction: The aim of tissue engineering is to fabricate structures called scaffolds to improve functions of the injured tissues/organs. Tissue engineering joined with nanotechnology is currently a promising alternative to the existing traditional repair strategies to create smart scaffolds for reconstruction of damaged tissues.
Methods: Scaffolds are fabricated based on two strategies; the conventional methods such as freeze drying, gas foaming, porogen leaching and electrospinning that are relatively cost effective and convenient procedures and the novel techniques such as rapid prototyping which provides more qualified control over physical properties including pore size and interconnectivity using computer aided designs.
Results: In recent years, nano carbon structures have been extensively studied for applying in the application of tissue engineering scaffolds. In fact, carbon and its derivatives with mechanical stability, biological compatibility, commercial availability and in particular specific chemical structures for facilitating cell-cell communication are promising candidates for biomedical applications such as tissue engineering and regenerative medicine. These nanomaterials have undeniable effects on angiogenesis which cause more efficient nutrient delivery inside the scaffold microenvironment.
Conclusion: Accordingly, in this article we highlight the potential and advantages of carbon-based nanomaterials as temporary structures in tissue engineering. Also, the major concerns about their unpredictable cytotoxicity in clinical application will be discussed.