مقالات پذیرفته شده در سومین کنگره بین المللی زیست پزشکی
Different Signatures of Circulating Exosomal MiRNAs in Cardiovascular Disease
Different Signatures of Circulating Exosomal MiRNAs in Cardiovascular Disease
Alireza Bahiraee,1,*Reyhane Ebrahimi,2Leila Setayesh,3Amirsaeed S. Aghabozorgi,4
1. Department of Medical Genetics, Faculty of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran. 2. Department of Clinical Biochemistry, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. 3. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran. 4. Department of Medical Genetics, Faculty of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.
Introduction: Cardiovascular diseases (CVDs) are one of the leading causes of morbidity and mortality. Standard therapies have failed to significantly increase patients’ survival. Moreover, the majority of conventional screening procedures are ineffective for the diagnosis of CVDs at early stages. Accumulating evidence suggests that numerous cell types release a class of nano‐sized vesicles named exosomes into the extracellular space. Exosomes are widely distributed in various body fluids and contain a number of diverse biomolecules such as proteins, lipids, and both mRNA and noncoding RNAs which reflect host‐cell molecular architecture. MicroRNAs (miRNAs), which can be found in exosomes, could be taken up by both neighboring and distal cells. Not only has recent evidence indicated the regulatory role of exosomal miRNAs in the pathogenesis of CVD, but it has also been shown that differential expression of exosomal miRNAs in CVDs has made them promising biomarkers for early detection of CVDs. Owing to these remarkable features, exosomal miRNAs have emerged as hot spots in research.
Methods: This review summarizes the role of exosomal miRNAs in the pathogenesis of CVDs and discusses their potential application in the clinical setting as both therapeutic and diagnostic tools.
Results: From an overall perspective, it has been shown that exosomes have a distinct population from other microvesicles and probably confer unique information on cardiovascular health and conditions. Hence, further analysis of their characteristics and their cargos are needed to investigate new biomarkers and diagnostic approaches of CVDs. The outlook of future medicine will be the implementation of such molecules in routine medical practice.
Conclusion: Consequently, regarding the significant roles of miRNAs in regulating adaptive and maladaptive cardiac remodeling, along with the roles of exosomes as carriers of miRNAs, exosomal microRNAs are believed to be a promising new therapeutic area in the future of cardiovascular medicine.