Induction of spermatogenesis by Bone Marrow-derived Mesenchymal stem cells (BM-MSCs) in Nonobstructive Azoospermic Hamster, Mouse and guinea pigs

Induction of spermatogenesis by Bone Marrow-derived Mesenchymal stem cells (BM-MSCs) in Nonobstructive Azoospermic Hamster, Mouse and guinea pigs
hossein bahrami moghaddam,^1,* reza kherdi,² neda pakray,³ Hamid Yazdaninejad,⁴ reza abooali,⁵
1. Medical Student, Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
2. Medical Student, Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
3. Medical Student, Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
4. B.S Student in Anesthesiology, Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
5. B.S Student in Medical Laboratory Science, Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
Introduction: : Non-obstructive azoospermia (NOA) is a type of infertility in men with limited therapies. busulfan is utilizing, For inducing animal models Non-obstructive azoospermia (NOA). In recent years, mesenchymal stem cells (MSCs) especially Bone Marrow-derived Mesenchymal stem cells (BM-MSCs) have opened up new opportunities for the treatment of various disorders, including infertility. Hence this article aim is comparison Induction of spermatogenesis by Bone Marrow-derived Mesenchymal stem cell therapy of Non-obstructive Azoospermic Hamster, Mouse and guinea pigs
Methods: : PubMed, Scopus, Cochrane library, Medline, Embase, and Web of Science were searched with the keywords " Spermatogenesis ",” Infertility “and " Nonobstructive Azoospermia ". A comprehensive analysis of all levels-of-evidence was done. Twenty-three articles discussing Nonobstructive Azoospermia were selected.
Results: : Our results showed After treatment of busulfan group with BM-SCs, spermatogonia, primary spermatocytes, spermatids and sperms were present in seminiferous tubules. spermatozoa were present in epididymis tubes too. seminiferous tubules that didn't have BM-SCs treatment, were empty.
Conclusion: As Transplanted BM-MSCs in seminiferous tubules induce repair of pathological changes and spermatogenesis, BM-SCs can be suggested as an effective treatment pattern in azoospermia. Further research is needed to prove the efficacy of this technique in human therapy
Keywords: " Spermatogenesis ",” Infertility “and " Nonobstructive Azoospermia "