مقالات پذیرفته شده در سومین کنگره بین المللی زیست پزشکی
Mycobacterium avium subsp. paratuberculosis: Concerns about Crohn's disease in humans
Mycobacterium avium subsp. paratuberculosis: Concerns about Crohn's disease in humans
Nazanin Moghaddam,1,*
1. Student of Laboratory Sciences, Islamic Azad University, Urmia Branchz, Urmia, Iran
Introduction: Mycobacterium avium subsp. paratuberculosis (MAP) is of great importance in public health. Because it is believed to be involved in the development of Crohn's disease (CD) in humans. A broad array of animal species, containing nonhuman primates, can be infected by MAP, making it quite plausible that it can also infect humans. Crohn's disease affects the terminal part of the ileum and colon, and in addition to this MAP, it is isolated from blood and tissue samples of humans with Crohn's disease.
Methods: The Google Scholar, PubMed, and Scopus databases were searched for the purpose of finding studies and 10 articles were studied.
Results: Studies using nested pcr and culture to detect the presence of MAP have identified the corresponding pathogen in patients with non-inflammatory bowel disease 26% and Crohn's disease 92%. In studies, Crohn's disease in Manitoba, Canada, was 15 of the 100,000 cases, the highest in the world, and increased due to high seroprevalence with the possibility of a link between high Crohn's disease and high MAP exposure. Infected animal milk can act as a means of transmitting contamination from animal to human, and laboratory studies of MAP heat tolerance have shown that pasteurization methods such as HTST (high-temperature short-time) for 15 to 25 seconds eliminate large amounts of MAP in milk. Meat consumed by humans has been identified as a potential source of MAP due largely to the contamination of carcass surface with faeces during the slaughter process. In addition to the presence of MAP at the carcass surface, it is separated from the liver, spleen, heart and lymph node tissues.
Conclusion: If Map is involved in Crohn's disease, contaminated milk and livestock can act as a means of transmitting contamination from animal to human. Since MAP is currently not recognized as a human pathogen by the regulatory authority, there are usually no restrictions on slaughterhouses identified as causing MAP infection, clinical and subclinical cases of cattle paratuberculosis.