مقالات پذیرفته شده در سومین کنگره بین المللی زیست پزشکی
Circular RNAs in Chronic myeloid leukemia
Circular RNAs in Chronic myeloid leukemia
Hanieh Beyrampour-Basmenj,1,*Rostam Rezaeian,2Jalal Mohammadi Khoshraj,3Kosar Babaei,4
1. Department of Medical Biotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran 2. Infectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran 3. Higher education Institute of Rab-Rashid, Tabriz, Iran 4. Tonekabon Azad University, Mazandaran, Iran
Introduction: Introduction
Covalently closed circular RNAs (circRNAs) are produced by precursor mRNA back-splicing of exons of thousands of genes in eukaryotes. circRNAs are generally expressed at low levels and often exhibit cell type-specific and tissue-specific patterns. Their high stability, abundance, and evolutionary conservation among species points to their distinct properties and diverse cellular functions as efficient microRNAs and protein sponges; they also play important roles in modulating transcription and splicing. CircRNAs has been demonstrated to play important roles in diverse biological processes, including differentiation, cell growth, and signaling. Aberrant expression of circRNAs has been found to be associated with various pathological processes, especially cancer. In this review, we survey the recent progress on circRNA biogenesis and function in chronic myeloid leukemia.
Methods: Methods
Based on our literature review from Scopus, Sciences direct, NCBI databases, about 70 paper was collected eventually 20 paper was reviewed which was near for our aim of study.
Results: Result
CircRNAs have been investigated for decades and emerging evidence indicates that circRNAs may play an important role in pathological functions, including a series of cancers. The comprehensive analysis was showed that some circRNAs could have the important role in pathogenesis of CML and also could have used as biomarker in disease diagnosis and prognosis. However, the role and molecular mechanism of circRNAs in leukemia are still not well demonstrated. The illustration of genome-wide circRNAs including their regulatory network may expand our knowledge for the molecular mechanism of CML.
Conclusion: Conclusion
In summary, the expression profiles of circRNAs were screened by high-throughput sequencing. A large number of aberrantly expressed circRNAs were identified in CML that is suggesting they may participate in disease progression and play important roles in cell development.