• Investigation of anti-epileptic drugs effects on expression of the genes associated with development of male mouse gonads
  • Marzieh Akbari,1 Ali Mohammad Ahadi,2,* Hoda Ayat,3
    1. Department of Genetics, Faculty of Science, Shahrekord university, Shahrekord, Iran,
    2. Department of Genetics, Faculty of Science, Shahrekord university, Shahrekord, Iran,
    3. Department of Genetics, Faculty of Science, Shahrekord university, Shahrekord, Iran,


  • Introduction: Epilepsy is one of the most prevalent neurological disorders that it affects about 1% of the world Society. Seizure patients controlling isn’t possible without antiepileptic drugs In many cases. Many studies have confirmed adverse side effects of these drugs.
  • Methods: In the present study, by collecting extensive information of previous researches, important key genes such as DOX1, WT1, SRY were identified in male gonads development and relevant gene networks was drawn by computer model. In the next step, by investigation the effect of Lamotrigenin and carbamazepine drugs and possible interactions with effective genes and molecules in the developmental pathway was predicted possible pattern of gene expression pathway and blocking or creating inter-network paths.
  • Results: Our results have shown that the above anti epileptic drugs can hurt the natural development of male gonads by disrupting the mentioned pathways.
  • Conclusion: These results emphasize the necessary to consider these cycles for the design of new drugs.
  • Keywords: Anti-epileptic drugs, Gene Network, Male Sexual Infertility