مقالات پذیرفته شده در سومین کنگره بین المللی زیست پزشکی
Treatment of multiple sclerosis using mesenchymal stem cells
Treatment of multiple sclerosis using mesenchymal stem cells
Rasul Saberi,1,*
1. Islamic Azad University of Mashhad
Introduction: Multiple sclerosis (MS) is a degenerative disease associated with dysregulation in matrix metalloproteinases (MMPs) and cerebellar hypo-perfusion.Current therapies, such as IFN beta and glucocorticoids, have little therapeutic effect and have only a soothing effect on patients with MS, however, given the unique properties of mesenchymal stem cells (MSCs), they can provide appropriate treatment options.
Methods: In this review study, with a review of 83 articles in the Google scholar and Pubmed databases, 26 articles from 2018 and 2019 were reviewed and reviewed.
Results: MSCs have an effect on microglycan phenotypes and a decrease in the M1 phenotype in MS to reduce anemia and reduce acne injuries, according to research.Likewise, amniotic mesenchymal stem cells (HAMSCs) have the ability to inhibit immune cells to the damaged site, increase the expression of neurotrophic factors, differentiate neuronal neuronal cells and reduce oxidative stress by increasing enzymes with antioxidant properties.Exosomes derived from bone marrow mesenchymal stem cells (BMSCs), by regulating the microglia polarization, have a diminished effect on inflammation and demyelinization, which ultimately lead to tissue improvement.
Conclusion: Also, the combination of Methylprednisolone with MSCs can be more effective in treating MS.Ultimately, compared to previous treatments that often prevent disease recurrence and stem cell transplantation, the drugs used in MS treatment, such as interferon drugs, have side effects that are sometimes severeWhile treating stem cells, an important side effect is unaffected, and the patient's improvement as a result of stem cell therapy can be a great alternative to the past treatment.