مقالات پذیرفته شده در سومین کنگره بین المللی زیست پزشکی
Study of genes network involved in the lipid metabolism and evaluation of the possible effect of Gamma Oryzanol
Study of genes network involved in the lipid metabolism and evaluation of the possible effect of Gamma Oryzanol
Parvin Vaseei,1,*Ali Mohammad Ahadi,2Hoda ayat,3
1. MSc student of Genetics, Shahrekord University, Shahrekord, Iran 2. Faculty member of Department of Genetics, Shahrekord University, Iran 3. Faculty member of Department of Genetics, Shahrekord University, Iran
Introduction: Obesity and metabolic syndrome are among the most common disorders of the last century, affecting more than 30% of the world's population. Understanding the genetic and biochemical pathways associated with metabolism and adjusting body fat levels will be a first step in designing and developing treatment strategies for patient population.
Besides, it is important to provide new therapeutic strategies that reduce the side effects and lower costs for people with these problems.
Methods: In this study, we first identified various molecules and factors involved in lipid metabolism and related cycles using different databases and servers, and after designing the gene network and plotting cross-linked pathways, we modeled the effect of the herbal drug Gamma Oryzanol on shifting pathways and predicting the expression changes of key and important genes including PPAR-α, Adiponectin and Glut 4. In vitro prediction is also being performed on model animals.
Results: Evaluation of our base model shows that Gamma Oryzanol is an alkaloid derived from rice can burn long-chain fatty acids by increasing the expression of PPAR-α, Adiponectin, and Glut 4 genes as well as increase metabolism rate and ultimately improve metabolic syndromes.
Conclusion: According to studies Gamma Oryzanol as an alkaloid can improve metabolic syndromes.