• Gut microbiome dysbiosis asdociates with parkinsin disease patophysiology; a systemetic rewiew
  • Zahra Karimi,1,* Anahita Hashempoor,2
    1. Student Research Committee,nursing student, Bushehr university of Medical Sciences, Faculty of Nursing and midwifery
    2. Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran


  • Introduction: Parkinson disease(PD) is a neurodegenerative disorder which is pathologically characterized by the presence of α-syncline deposits and lewi bodies in the brain. The initiation of pathological processes is still unclear therefore prevention, early diagnosis and early treatment have been unachievable. Recently growing evidences have highlighted the role of got microbiome on both the enteric nervous system (ENS) and the central nervous system (CNS) dysfunction which is supported by a series of gastrointestinal (GI) disorders associating with PD including weight loss, gastroparesis, constipation and defecation disorders. So in this study we aimed to investigate the role of got microbiome dysbiosis in the initiation of PD pathophysiology in order to unravel the potential use of microbiome targeted therapies.
  • Methods: An electronic search was performed in PubMed, SCOPUS, Science direct, EBSCO, ProQuest for literature published up to October 2019 by keywords including Parkinson's disease, microbiota and gut microbiome. our search was limited to the English language. The extracted papers were studied based on inclusion criteria, and 52 articles from all obtained studies were selected in order to consider in the current study.
  • Results: This analysis illustrates the role of gut microbiota in PD pathophysiology. Studies have shown that there is a close relationship between microbiota dysbiosis and neurological disorders such as PD. Some studies showed that the relative abundance of Lactobacillaceae, Enterobacteriaceae and Enterococcaceae families are higher in feces of PD patients, whilst the abundance of Lachnospiraceae family was at lower level. Decreasing in Lachnospiraceae and increasing in Enterobacteriaceae abundance may have an association with disease progression and motor impairment, but additional data are needed for the acknowledgement of this hypothesis. In contrast, some studies reported that Lactobacillaceae and Enterococcaceae have been decreased in PD patients. some studies reported various result about the abundant of Prevotella genus, maybe it is due to the more dependency of this genus to dietary habits or differences in inclusion criteria. Investigating the stool sample of patients with PD revealed higher level of inflammatory factors. Their significant role in neural damage is through their derivatives such as oxidative components and cytokines which induce PD related neuroinflammation. it is still unclear whether inflammation leads to microbiota alternation or vice versa.
  • Conclusion: gut microbiome dysbiosis have recently raised a lot of attention for its possible role in the pathogenesis of many diseases particularly neurodegenerative disorders. Dysfunction of mucosal barriers in the gut (leaky gut) may lead to infiltration of various inflammatory mediators and reactive oxygen species produced by gut microbes into the blood stream and will cause injury to the blood brain barrier leading to (leaky brain). Blood brain barrier is considered to be a vital importance for maintaining brain function therefore the abundance and composition of gut microbiome may serve as a new target for prevention and early treatment of Parkinson disease.
  • Keywords: gut microbiota,microbiome,parkinson disease