Introduction: Colorectal cancer is one of the most common gastrointestinal cancers in the world. About 1.2 million cases of colon cancer occur worldwide each year, leading to death in about 50% of cases. Colon tumors are the second most common gastrointestinal tumor in the world and the third most common tumor in women in Iran and the fifth most common in men. And in recent years we have seen a dramatic increase in colorectal cancer in countries around the world. Ulcerative colitis , is a form of inflammatory bowel disease that affects the colon, especially the colon, including the colon and rectum. It is found in different countries around the world. But the prevalence can be as high as 50 to 80 per 100,000. ulcerative colitis can lead to colorectal cancer.The purpose of this study was to evaluate the prevalence of colorectal cancer in people with ulcerative colitis.
Methods: We searched pubmed and Google scholar databases until 2019 prevalence,colorectal cancer and ulcerative colitis keywords.
By searching these databases ,116 articles were found in pubmed from 1984_2019,and 300 articles were found in Google scholar from 2000.
From 416 articles with investigating titles, we exclude 333 articles ,and with reading abstract we exclude 52 articles.
Finally we include 31 articles into our study.
Results: In one article, the overall prevalence of CRC in each patient with ulcerative colitis was estimated to be 3.7%, with an overall incidence of 3 in 1000 and an incidence of 6 in 1000 children. For the first 10 years, the incidence was 2 in 1000. And for the second decade was 7in1000 and in the third decade had an incidence of 12in 1000.This corresponds to a cumulative probability of 2% at 10 years,8% at 20 years and18% at 30 years. In the United States, the prevalence is 5 in 1000, in England 4 in 1000 and in Scandinavia and other countries 2 in 1000.
In another article, the prevalence of CRC in patients with UC in Korea was .37%, and the cumulative risk was .7% at 10 years and 7.9% at 20 years and at 33.2% at 30 years.
The overall prevalence in the Asian study was .85%, and the risk of colon cancer was .02% at 10 years, 4 .81% at 20 years, and 13.91% at 30 years.
In a Chinese study, CRC occurred in 2.8% of patients with ulcerative colitis.
In one article, the cumulative probabilities of the risk of CRC were estimated to be 4.4% at 10 years, at 8.6% at 20 years and at 12.7% at 30 years.
other articles reviewed also show the incidence of CRC in patients with ulcerative colitis, at 1.58 per 1000 patients, at 4.07 per 1000 patients in the second decade of life, and at 4.55 per 1000 patient in the third decade of the disease.
Conclusion: According to the results, the prevalence of colorectal cancer in ulcerative colitis patients is higher than normal people, so this risk is related to the location and extent of ulcerative colitis. Therefore, it is recommended that people with ulcerative colitis undergo biopsy testing and harvesting every two years to prevent colorectal cancer and adopt a healthy diet. However, further studies are needed.