• Interaction of TCF7L2 gene polymorphisms and diet: a potential opportunity for personalized treatment and prevention of diabetes mellitus type 2
  • Fatemeh Karami,1,* Malikeh Mohajerani ,2
    1. Department of Medical Genetics, Applied Biophotonics Research Center, Science and Research Branch, Islamic Azad University, Tehran, Iran
    2. Department of Nutrition, Applied Biophotonics Research Center, Science and Research Branch, Islamic Azad University, Tehran, Iran


  • Introduction: Diabetes mellitus type 2 (T2DM) is one of the most important metabolic disease which its prevalence is dramatically increased. Polymorphisms of TCF7L2 gene have been shown meaningful association with T2DM in different populations as well as Iranians. Owing to the pivotal role of dietary restrictions in management of T2DM patients and recent focuses on the interaction between diet type and TCF7L2 gene polymorphisms in T2DM progression, current study was aimed to review those correlations in various studies performed around the world.
  • Methods: Systematic review study was performed using Diabetes mellitus type 2, TCF7L2, gene polymorphism, diet and interaction key words. PubMed, Sciencedirect, Googlescholar and Scopous were the main search engines used to find and categorize the apprpriate manuscripts.
  • Results: It was found that the effect of TCF7L2 gene polymorphism on T2DM disease progression has been aggaregated with every dietary elements which was associated insuline resistance. In addition, high fiber diet was mostly effective in T2DM patients witout risk allele of TCF7L2 gene polymorphism.
  • Conclusion: The results are indicating that the type of diet selected for T2DM patients would not be helpful for all of them and is influenced by the genotypes of risk alleles. In this regard, genotyping of the T2DM patients not only could pave the way toward early prevention of later side effects of the disease, but also could determine the best choice of diet in order to manage the disease as much as possible.
  • Keywords: diet, TCF7L2, gene, polymorphism, Diabetes mellitus type 2