Introduction: In recent years, in the field of drug therapy, the drug has been distributed in a controlled manner. Extensive research has been done to reduce the side effects of drugs. New nano-sized drug delivery systems have been developed to overcome the side effects of drugs. Among the many nanoparticles of protein nanoparticles that have many applications in medicine and medicine, proteins have been extensively studied and controlled as a means of transferring therapeutic agents to desired parts of the body. The reason for using proteins in relation to other polymers such as lipids, polysaccharides, etc., is biodegradable, edible, lacks toxicity and availability, as well as lack of immune response from the immune cells when received in the body. is On the other hand, its physical properties and surface charge make it a suitable carrier for hydrophobic drugs. The purpose of this study was to review the fabrication of suitable protein nanoparticles in terms of size and quality in order to intelligently and deliberately transfer drugs to desired locations in the body.
Methods: Research on plant proteins and animal proteins such as milk, eggs, soybeans, etc. has recently been investigated for applications in drug delivery, and this represents a development in the application of functional protein nanomaterials in the food industry as The drug carrier is very promising.
Results: The commercial success of albumin-based nanoparticles has generated great interest in the use of other proteins. In fact, protein nanoparticle-based drugs are becoming a leading strategy potentially for cancer treatment due to higher selectivity, reduced toxicity, clearance and increased efficacy compared to conventional systemic therapies.
Conclusion: In summary, a novel approach for development in drug delivery and cancer treatment is nanoparticles in drug delivery that have a major impact on the treatment of cancer and other life-threatening diseases. There is a great need for nanoparticles as drug carriers that are safe and effective in identifying the cause of the disease and treating it in providing therapeutic agents to the desired parts of the body. Proteins are natural-source polymers as promising materials for international research as nanosized drug carriers that due to their excellent biocompatibility, the process of simple and easy preparation of nanoscale proteins as efficient protein nanoparticles Drug transfer and cancer treatment are important compared to other polymers such as lipids and polysaccharides. Increased intracellular antitumor activity in drug delivery by protein nanoparticles as drug carriers is clearly seen compared to the formulation of conventional pharmaceuticals. As a result, it is clear that protein nanoparticles are capable of carrying multiple hydrophilic and hydrophobic drugs simultaneously, detecting and treating cancer cells. Research on plant proteins and animal proteins such as milk has recently been investigated for applications in drug delivery, and this indicates the development of the application of edible protein nanomaterials as drug carriers, which is very promising. The commercial success of albumin-based nanoparticles has generated great interest in the use of other proteins. In addition, multifunctional protein nanoparticles are now being able to carry both therapeutic and diagnostic agents for more effective management of developmental cancer. Although the use of protein nanoparticles for cancer treatment has already produced exciting results, the therapeutic performance and therapeutic efficacy of protein nanoparticles still require further research. Recently, the clinical approval of protein nanoparticles demonstrates the value of nanotechnology for the treatment of cancer. In the future, suggesting more effective ways to deliver medication to the bloodstream is to selectively target tumor cells. In pharmaceutical preparations, the molecules needed to improve the solubility of drugs in water mainly depend on the absence of substances capable of overcoming the problems of rapid drug delivery. The report suggests that many interesting alternatives are emerging based on the use of proteins, so more research is needed, the promising results so far fully justifying the further efforts of both economic support. And research in this area.
Keywords: : Protein Nanoparticles, Applied in Food Industry, Pharmaceutical Carriers, Cancer Treatment