مقالات پذیرفته شده در سومین کنگره بین المللی زیست پزشکی
The modulating effect of vitamin D levels on cytokine expression in patients with urinary tract infection
The modulating effect of vitamin D levels on cytokine expression in patients with urinary tract infection
Leila Pirdel,1,*Manijeh Pirdel,2
1. Islamic Azad University, Ardabil Branch 2. Islamic Azad University, Astara Branch
Introduction: Vitamin D plays a major role not only in the regulation of bone metabolism but also in the modulation of the immune responses. We aimed to determine whether vitamin D modulated cytokines production in patients with urinary tract infection (UTI) and any association might be seen between serum vitamin D levels and this response as well.
Methods: In this study, women (65 in the patient group and 35 in the control group), who were between 18-60 years old, were studied. The serum levels of 25(OH) vitamin D and cytokines, including IFN-γ, IL-4, IL-17A and TGF-1, were measured by using ELISA kits.
Results: A significant decrease in vitamin D levels was shown in patients compared to the control group. The results showed that both IFN-γ and IL-17A production increased in patients compared with those of the controls and these cytokines correlated inversely with serum 25(OH)D levels. Despite reduced production of IL-4 in patients, no significant difference was found between the two groups. However, its production level was correlated positively with serum 25(OH)D levels. Moreover, the increased levels of TGF-β1 in patients indicated a significant positive correlation with serum 25(OH)D levels.
Conclusion: It is suggested that vitamin D might be contributed independently to the modulation of Th1and Th17 responses to infection; the effect of vitamin D on the response to infection is complex requiring further investigation.