• polymeric nanofibers in vascular Tissue Engineering
  • Sonia Fathi Karkan,1,* Reza Maleki Baladi,2 Reza Rahbar Ghazi,3
    1. Department of medical Nanotechnology, faculty of Advanced Medical Science, Tabriz University of medical sciences, Tabriz, Iran
    2. Young Researchers and Elite Club, Tabriz Branch, Islamic Azad University, Tabriz, Iran
    3. Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran


  • Introduction: Since cardiovascular disease is one of the most important causes of human death worldwide, it is important to address this issue.Tissue engineering is an interdisciplinary scientific field that applies different methodologies to circumvent problems associated with tissue injury or organ loss.If a vessel gets clogged or an aneurysm needs major repair and there is a reason not to use angioplasty then the importance of artificial vascular grafts becomes clear.
  • Methods: The use of electrospinning is very common in the preparation of polymer fibers. Synthetic grafts are made of woven tubular fibers such as polyesters and poly tetrafluoroethylene.
  • Results: Various commercial products can also be combined with surface coatings to Resistance to clotting
  • Conclusion: The construction of scaffold by Electrospining for tissue engineering became a popular method. And it seems to have a great deal of ability to build scaffolds with specific structural and functional features. Scaffolds used in vascular tissue engineering should have a layered structure, as well as biocompatibility and anticoagulant properties should be taken into consideration. A limited number of studies have been conducted based on the use of electrospun scaffolds and no studies have ever been done in in vivo.
  • Keywords: vascular tissue engineering, electrospun nano fibers, polymeric fiber