• The Effect of Green Coffee Extract Supplementation on Blood Pressure: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
  • Hamed Kord-Varkaneh,1,* Baizhi Han,2 Cain C. T. Clark,3 Reyhaneh Rasekhmagham,4
    1. Student Research Committee, Department of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, ShahidBeheshti University of Medical Sciences,Tehran, Iran
    2. Department of general medicine, Affiliated Hospital of Weifang Medical University, No.2428 Yuhe Road, Kuiwen District, Weifang, Shandong Province, 261031, China
    3. Centre for Sport, Exercise and Life Sciences, Coventry University, Coventry, CV15FB, U.K.
    4. Department of Nutrition,Faculty of Medical Sciences, Science and research Branch,Islamic Azad University


  • Introduction: Given the proliferation in studies investigating green coffee bean extract (GCBE) supplementation, the purpose of this study was to determine the efficacy and effectiveness of GCBE supplementation on indices of blood pressure.
  • Methods: The literature search was performed in four databases including PubMed/Medline, Scopus, the Cochrane Library, and Google Scholar to identify clinical trials that examined the effects of green coffee supplements on SBP and DBP up to February 2019. Mean change and standard deviation (SD) of the outcome measures were used to estimate the mean difference between the intervention group and the control group at follow-up. Nine studies including reported SBP and DBP as an outcome measure.
  • Results: Results revealed significant reduction in SBP (WMD: -3.093 mmHg, 95% CI: -3.914, -2.273; I2 = 0.0%) and DBP (-2.170 mmHg, 95% CI: -2.749, -1.590; I2= 46.5%) after green coffee supplementation with low heterogeneity among the studies. In addition, in sub-group analysis, a significant reduction in SBP and DBP in studies with hypertensive patients, green coffee dosage <400 mg, and administered for 4 weeks was identified.
  • Conclusion: The results of current meta-analysis study support the use of GCBE supplementation for the improvement of blood pressure indices, with sub-group analysis highlighting improvements in hypertensive patients.
  • Keywords: Meta-analysis, Blood Pressure, SBP, DBP, Green-Coffee.