مقالات پذیرفته شده در سومین کنگره بین المللی زیست پزشکی
Lipidomics of Adipogenic Differentiation of Mesenchymal Stem Cells
Lipidomics of Adipogenic Differentiation of Mesenchymal Stem Cells
Kambiz Gilany,1Moloud Payab,2Parisa Goodarzi,3Akram Tayanloo-Beik ,4Motahareh Sheikh Hosseini,5 Babak Arjmand,6,*
1. Reproductive Immunology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran. Department of Biomedical Sciences, University of Antwerp, Belgium. Integrative Oncology Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, Iran 2. Obesity and Eating Habits Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran 3. Brain and Spinal Cord Injury Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran 4. Cell Therapy and Regenerative Medicine Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran 5. Metabolomics and Genomics Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran 6. Cell Therapy and Regenerative Medicine Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran. Metabolomics and Genomics Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran Unive
Introduction: Mesenchymal stem cells are defined as multipotent cells which have the ability to differentiate to various types of cell. Under the adipogenic stimuli, mesenchymal stem cells possess the ability to differentiate into adipocytes through adipogenesis processes. Adipogenesis is defined as the process of pre-adipocyte differentiation to mature adipocytes. Adipocytes are a type of cells with the ability to maintain energy balance through storage excess energy. Accordingly, obesity as a worldwide problem is one of the prevalent outcomes of increasing fat mass that there is a global effort to combat it.
Methods: The authors have used 142 papers extracted from databases Web of Science, PubMed, and Scopus to search for more efficient methods to the investigation of adipocytes, prognosis and prevent obesity.
Results: Hypertrophic adipocyte can secrete several endocrine factors that induce hyperplasia (one of the major causes of obesity) and signal proliferation and differentiation of preadipocytes. Therefore, it has been demonstrated that mesenchymal stem cells adipogenic differentiation undergoes different signaling pathways with various regulatory factors that elucidation of these controllers can help to the discovery of more effective treatments for obesity and other related diseases.
Conclusion: lipidomics has been introduced as an emerging field of biomedicine. Through the large-scale analysis of lipids, lipidomics provides more efficient methods to the investigation of adipocytes, prognosis and prevent obesity.