• OMICs Profiling of Cancer Cells
  • Bagher Larijani,1 Motahareh Sheikh Hosseini,2 Sepideh Alavi-Moghadam ,3 Masoumeh Sarvari,4 Mina Abedi,5 Moloud Payab,6,*
    1. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical sciences, Tehran, Iran
    2. Metabolomics and Genomics Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
    3. Cell Therapy and Regenerative Medicine Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
    4. Cell Therapy and Regenerative Medicine Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
    5. Cell Therapy and Regenerative Medicine Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
    6. Obesity and Eating Habits Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran


  • Introduction: Cancer is a complex disease caused by several factors such as genetics, epigenetics, proteomics, and transcriptional alterations of cellular damage that is resulted from several factors through genetic mutations and environmental effects. Early diagnosis has a pivotal role in the treatment or improving outcomes of cancer. Therefore, detecting cancer at early stages is a key challenge in cancer medicine and increases the survival rate. For early diagnosis, some genetics, proteomics and metabolomics profiling should be considered using OMICs technologies.
  • Methods: The authors have used 57 papers extracted from databases Web of Science, PubMed, and Scopus to search for identifying novel targets such as applying OMICs technology in the treatment of cancer.
  • Results: OMICs’ technologies mainly focus on the detection of entire genes which is applied into genomics, mRNA (transcriptomics), proteins (proteomics), metabolites (metabolomics), and lipids (lipidomics) in cells. OMICs technologies, which system biology bring, are valuable tools for comprehensive analysis around cancer treatment.
  • Conclusion: future analyzing of OMICs data can increase our therapeutic productivity for molecular targets of cancer therapies. The data of cancer OMICs are rapidly collected and provided an invaluable resource for identifying novel targets in the treatment of cancer and will accelerate with developed diagnostic technologies and advanced novel methods in the near future.
  • Keywords: Biomarker; Cancer; Early Detection; OMICs Technology; Treatment Accosiatiated