مقالات پذیرفته شده در سومین کنگره بین المللی زیست پزشکی
Therapeutic abortion and ectopic pregnancy: alternative sources for fetal stem cell research and therapy in Iran as an Islamic country
Therapeutic abortion and ectopic pregnancy: alternative sources for fetal stem cell research and therapy in Iran as an Islamic country
Parisa Goodarzi,1Khadijeh Falahzadeh,2Bagher Larijani ,3Sepideh Alavi-Moghadam ,4Akram Tayanloo-Beik,5 Babak Arjmand,6,*
1. Brain and Spinal Cord Injury Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran 2. Metabolomics and Genomics Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran 3. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical sciences, Tehran, Iran 4. Cell Therapy and Regenerative Medicine Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran 5. Cell Therapy and Regenerative Medicine Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran 6. Cell Therapy and Regenerative Medicine Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran. Metabolomics and Genomics Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran Unive
Introduction: Regenerative medicine as a background of stem cell research and therapy has a long history. A wide variety of diseases are a candidate to be treated using different types of stem cells. There are several sources of stem cells such as bone marrow, umbilical cord, peripheral blood, germ cells, and the embryo/fetus tissues. Fetal stem cells and embryonic stem cells have been described as the most potent stem cell source. Although their prior multipotent properties leads to promising reports for their clinical applications, owning to some ethical and legal obstacles in different communities such as Muslim countries, care should be taken for therapeutic applications of FSCs and ESCs. Derivation of these cell types needs termination of pregnancy and embryo or fetus life that is prohibited by nearly all the major world religions.
Methods: A systematic search of different published articles was conducted. Several databases such as PubMed, Google Scholar, Scopus, etc. were searched using specific keywords related to the article title.
Results: A total of 148 studies resulted in this study. Relevant data was gathered by the authors and reviewed properly to write the manuscript.
Conclusion: The authors suggest that the utilization of ectopic pregnancy conceptus, extra-embryonic tissues, and therapeutic abortion materials as a valuable source of stem cells for research and medical purposes can overcome limitations associated with finding the appropriate stem cell source.