Introduction: It has been demonstrated that Polycystic Ovary syndrome (PCOS) may be associated with insulin resistance and oxidative stress state. Hyperglycemia induced oxidative stress may alter the structural and functional changes in kidney and pancreatic 𝛽cells and eventually results in diabetic microvascular and macrovascular complications. Here, we investigated effects of resveratrol on oxidative status in the rat models of PCOS. The main purpose of this study was to evaluate effects of oxidative stress biomarkers malondialdehyde (MDA) and total antioxidant capacity (TAC) in kidney and pancreas tissues in the rat model of PCOS.
Methods: Ten female rats (21 day-old) were used in 2groups as follows: I) The Control group: had no treatment. II) The PCOS group: in this group testosterone enanthate 10mg/kg was injected for 35 days once daily to induction of PCOS phenotype. III) The PCOS-Resveratrol, after receiving testosterone to induction of PCOS resveratrol was administered 10mg/kg intrapritoneally for 28 days. At the end of treatments, the fasting levels of MDA, and TAC in kidney and pancreas tissues were determined by using an Agilent Technologies 1200 Series HPLC system and commercially TAC kit respectively.
Results: There were not significant differences in the mean of MDA and TAC levels of the two groups (p<0.05). However, treatment with resveratrol for 28 days, decreased these parameters in the rat models of PCOS (p<0.05).
Conclusion: Resveratrol usage can improve oxidation status in kidney and pancreas tissues in PCOS.