مقالات پذیرفته شده در سومین کنگره بین المللی زیست پزشکی
Development and validation of Alzheimer’s Disease Animal Model for the Purpose of Regenerative Medicine
Development and validation of Alzheimer’s Disease Animal Model for the Purpose of Regenerative Medicine
Moloud Payab,1Sepideh Alavi-Moghadam,2Masoumeh Sarvari ,3Najmeh Foroughi Heravani,4Mahdieh Hadavandkhani ,5 Babak Arjmand,6,*
1. Obesity and Eating Habits Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran 2. Cell Therapy and Regenerative Medicine Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran 3. Cell Therapy and Regenerative Medicine Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran 4. Cell Therapy and Regenerative Medicine Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran 5. Metabolomics and Genomics Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran 6. Cell Therapy and Regenerative Medicine Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran. Metabolomics and Genomics Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran
Introduction: One of the most common age-related neurodegenerative disorders is Alzheimer’s disease which globally threatening the health of elderly people. Although there are several pharmacological and non- pharmacological treatments for Alzheimer’s disease, they can just decrease the symptoms in these diseases. In this context, cell therapy and regenerative medicine approach as the novel therapeutic strategies for neurodegenerative diseases would be important. Based on scientific research principles, using any novel therapeutic approaches before the run in clinical trials need to take preclinical (animal study) stapes. Accordingly, an animal study can improve our understanding of biological mechanisms of diseases and as an important step should adhering to ethical guidelines and standards. On the other hand, to gain suitable outcomes, it is important to check the appropriate validation of animal models. In this regard, the present review would discuss about the development and validation of appropriate AD animal models in the field of regenerative medicine.
Methods: Overall, 78 articles were reviewed. Relevant articles were identified via searches of Pub Med and Google Scholar databases.
Results: Consequently, preclinical animal studies before running in clinical trials can evaluate the effects of therapeutic agents. Herein, validation methods lead to valid animal models which are similar to the human in disease etiology, pathophysiology, symptomatology, and responses to treatments.
Conclusion: Animal models as important resources for in vivo studies are validated through various methods of validation. In the case of Alzheimer, behavioral tests and imaging are employed in validation process of animal models. and principles for the ethical use of them. Anyway, novel technologies are required to perform the principles for the ethical use of animals.