مقالات پذیرفته شده در سومین کنگره بین المللی زیست پزشکی
Metabolomics and Cell Therapy in Diabetes Mellitus
Metabolomics and Cell Therapy in Diabetes Mellitus
Parisa Goodarzi ,1Moloud Payab,2Sepideh Alavi-Moghadam ,3Mina Abedi,4Maryam Arabi,5 Babak Arjmand,6,*
1. Brain and Spinal Cord Injury Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran 2. Obesity and Eating Habits Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran 3. Cell Therapy and Regenerative Medicine Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran 4. Cell Therapy and Regenerative Medicine Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran 5. Metabolomics and Genomics Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran 6. Cell Therapy and Regenerative Medicine Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran. Metabolomics and Genomics Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran
Introduction: Diabetes with a broad spectrum of complications has become a global epidemic metabolic disorder. Till now, several pharmaceutical and non-pharmaceutical therapeutic approaches were applied for its treatment. Nowadays, cell-based therapies have become a promising method for diabetes treatment. Better realize of diabetes pathogenesis and identify its specific biomarkers along with the evaluation of different treatments efficacy, can be possible by clarification of specific metabolic modifications during the diabetes progression. Subsequently, metabolomics technology can support achieving this goal as an effective tool. Herein, the present review is tried to identify how metabolomics quantifications can be useful for diabetic monitoring before and after cell therapy.
Methods: In this review, 72 articles extracted from PubMed, Scopus, and Web of Science databases were used to search around cell therapy and metabolomics in diabetes.
Results: Cell therapy is an alternative approach to achieve diabetes treatments goals including insulin resistance amelioration, insulin independence reparation, and control of glycemia. On the other hand, OMICs approaches provide a comprehensive insight into the molecular mechanisms of cells features and functional mechanism of their genomic, transcriptomic, proteomic, and metabolomic profile which can be useful for their therapeutic application. Metabolomics as modern technology for the detection and analysis of metabolites in biological samples can identify many of the metabolic and molecular pathways associated with DM and its following complications.
Conclusion: Metabolomics progression has been helpful for discovering special disease biomarkers to assess the functional mechanisms of novel treatments in addition to realizing the pathogenesis mechanism of disease.