مقالات پذیرفته شده در سومین کنگره بین المللی زیست پزشکی
Allele G of the rs1736932 polymorphism of the promoter region of HLA-G may enhance the risk of recurrent spontaneous abortion in the women population from Northwest of Iran
Allele G of the rs1736932 polymorphism of the promoter region of HLA-G may enhance the risk of recurrent spontaneous abortion in the women population from Northwest of Iran
Introduction: In human pregnancies HLA-G (Human leukocyte antigens G) is supposed to play a main role in implantation. It is expressed on trophoblast cells that invades during pregnancy to the uterus decidua and induce maternal immunological tolerance against the fetus. The aim of the present study was to investigate the association of rs1736932 with the recurrent spontaneous abortion (RSA) in women from the northwest of Iran.
Methods: In this case-control study, the HLA-G gene rs1736932 polymorphism in 100 women with history of recurrent abortion as a case group and 80 women without history RSA as a control group were analyzed using PCR-sequencing method. Fisher's exact test was used for comparison of Allele and genotype frequencies between the case and control groups.
Results: In the rs1736932 polymorphism, the frequency of CC, CG and GG genotypes were 8%, 32% and 60% in patient group and 17.5%, 41.25% and 41.25% in control group, respectively. Frequency of C and G alleles in patients was 24% and 76% and in control group was 38.125% and 61.875%, respectively. Statistical analysis showed that GG genotype was associated with the recurrent miscarriage (P = 0.005, OR=2.136) and the allele G was identified as a risk allele for the recurrent spontaneous abortion (P = 0.011, OR=1.951).
Conclusion: This study showed a significant association between rs1736932 polymorphism and RSA in northwestern Iranian women.