مقالات پذیرفته شده در سومین کنگره بین المللی زیست پزشکی
The Association Between Serum Oxidative Stress Indexes and Pathogenesis of Parkinson's Disease in the Northwest of Iran
The Association Between Serum Oxidative Stress Indexes and Pathogenesis of Parkinson's Disease in the Northwest of Iran
Mohsen Hemmati Dinarvand,1,*Samira Saedi,2
1. Department of Clinical Biochemistry, Faculty of Medicine, Shiraz University Of Medical Sciences, Shiraz, Iran 2. Department of Medical Microbiology, Faculty of Medicine, Kurdistan University Of Medical Sciences, Kurdistan , Iran
Introduction: Parkinson's disease (PD) is a prevalent neurodegenerative disorder. It has been believed that oxidative stress is a main modulator in the advancement of PD. This investigation aimed to evaluate the relations between serum trace elements, vitamin C, ferritin, transferrin, Nitrite Oxide (NOx) and Peroxynitrite (PrN) concentrations and clinical parameters in patients with PD.
Methods: Serum concentrations of trace elements, vitamin C, ferritin, transferrin, NOx, and PrN were measured in 75 PD patients and 75 healthy subjects. Receiver Operating Characteristic (ROC) analysis was performed to examine incremental diagnostic value of vitamin C, NOx, and PrN in the study groups.
Results: Mean serum NOx (35.81±5.16 vs. 11.27±3.59 mol/L, p < 0.001) and PrN (15.78±4.23 vs. 9.62±4.57 mol/L, p= 0.004) were markedly higher in patient group versus healthy individuals. Significant differences were also observed in the serum levels of vitamin C (p <0.001), copper (Cu) (p<0.001), Iron (Fe) (p= 0.003), and Zinc (Zn) (p<0.001) between patients with PD and healthy subjects. Nevertheless, the serum levels of Se (p=0.515), ferritin (p=0.103), and transferrin (p= 0.372) were not statistically significant between the study groups. ROC analysis has revealed a diagnostic ability of serum vitamin C levels for PD with an area under ROC curve of ≥0.7 (p < 0.05) and relatively high sensitivity and specificity.
Conclusion: Our results showed that serum levels of NOx and PrN are significantly higher in the patients with PD. Also, the serum concentrations of Cu, Zn, and vitamin C in healthy subjects were higher than in PD patients. In additions, it has been shown that serum vitamin C levels have a diagnostic value as a biomarker. Further studies are required with larger sample size to provide more detailed information about the cognitive profile of participants and the outcome measures.