Introduction: Background & Aims: Leukemia is a type of hematopoietic malignancy associated with malignant white blood cell proliferation. In acute lymphoid leukemia (ALL), a large number of lymphocytes that have not yet fully developed, are impaired and are increasingly found in peripheral blood and bone marrow. The MDM2 gene promoter is the most well-known polymorphism of this gene, where substitution of T nucleotide by G at this site results in increased MDM2 gene expression. Frequency of single nucleotide locus mutations .
Methods: materials and Methods: In the present study, the polymorphism of MDM2 gene was investigated using RFLP-PCR and sequencing of 5 blood samples from patients with ALL.
Results: The results: show that there is a statistically significant association between MDM2 polymorphism and ALL patients. Frequency of TT, TG and GG genotypes in this study was 5%, 2% and 3% in the case group and 2%, 2% and 5% in the control group, respectively. According to the value-P presented for all three genotypes (P = 0.2), genotypic distribution of this polymorphism was significantly associated with ALL disease.
Conclusion: Conclusion: The present study shows that the MDM2 gene promoter polymorphism has a significant association with locus of acute myeloid leukemia in Khuzestan population.