• In Silico Analysis on Structural and Functional Effect of a Deleterious SNP of BRCA1 Gene Associated with Prostate Cancer
  • Maryam Hakimi,1 Hamid Saadati,2 Shirin Farivar,3,*
    1. Life Sciences and Biotechnology Faculty of Shahid Beheshti University
    2. Department of Biology, Faculty of science, Yazd University, Yazd, Iran
    3. Life Sciences and Biotechnology Faculty of Shahid Beheshti University


  • Introduction: Prostate cancer is one of the common diseases in men. In this cancer, certain cells in prostate gland turn to abnormal cells, which lead to uncontrolled cell proliferation. Having inherited genetic mutations in particular genes, such as BRCA1, BRCA2, and HOXB13, are important to some cases of hereditary prostate cancer. BRCA1 is located on chromosome 17q21.31, and the protein produced by this gene, is important for repairing DNA damage, which leads to keeping the genetic stability. Because of this, this gene is considered as tumor suppressor gene, that prevents cells from uncontrolled proliferation.
  • Methods: In this study, rs55770810 has been investigated by SIFT, ExPASy, PSIPRED, PolyPhen, and I-Mutant servers. With these servers the effect of this mutation on structure and features of the expressed protein was searched.
  • Results: These servers predicted that this mutation is harmful. Results determined that this mutation changes the hydropathic index from -4.500 to -0.900.
  • Conclusion: This study suggests that R595W mutation of BRCA1 can have effect on amino acid interactions and protein resistance.
  • Keywords: Prostate cancer, SNP, BRCA1, Mutation, Secondary structure