• Evaluation of Stem Cell-Based Personalized Medicine in the Treatment of Type 1 Diabetes
  • Abbas Mousavand,1,* Abdulghafar Alizadeh,2 Mahdi Shirazi,3
    1. Islamic Azad university , Varamin-Pishva branch
    2. Islamic Azad university , Varamin-Pishva branch
    3. Islamic Azad university , Varamin-Pishva branch


  • Introduction: Mesenchymal stem cells (mscs) are the most widely used stem cells of the human body because of successful isolation, and expansion for many years. it is explicit that diabetes mellitus (DM) is a widespread chronic disease. therefore, msc transplantation may be a beneficial treatment for both types of this disease. Diabetes is a type of glucose metabolism disorder characterized by high blood glucose levels. The disease affects around 350 million people around the world, rising steadily and is expected to increase sharply in the near future. Type 1 diabetes is an autoimmune disease in which immune cells invade insulin secreting stem cells and cause damage to insulin stem cells in the Langerhans Pancreas, leading to insulin secretion. Extensive research has been conducted to replace cell therapy and the use of stem cells. Stem cells are capable of replacing damaged cells in the body. Therefore, they offer a promising method for replacing inactive insulin-producing pancreatic beta cells. Also, the use of a variety of gene therapy methods for the treatment of diabetes has yielded more favorable results than the previous method of insulin delivery. Due to the fact that constant control over insulin consumption is vital, the external insulin treatment method for diabetic patients has failed to mimic insulin secretion in healthy beta cells. Therefore, foreign insulin is a way to save lives rather than cure. The purpose of this article is to examine most recent advances in gene therapy and stem cell methods as a novel way of treating diabetes.
  • Methods: Surveying different articles related to the subject in recent years with Using several internet search engines like google chrome, Pubmed, and Scopus.
  • Results: In order to treat both types of DM, mesenchymal stem cells play an important role in the repair of tissues such as bone, cartilage, and muscle. Also, embryonic stem cells can help us to treat the beta cells of the langerhans, and this alternative treatment is a better option than the old insulin injection method.
  • Conclusion: In summary, by studying recent papers, it can be concluded that the MSC and ESC transplantation, despite concerns and costs, can be a good and permanent treatment for DM, since stem cells today are one of the newest treatments for the disease. Also, the use of stem cell therapy in the treatment of type 1 diabetes can reduce the cost of treatment and care of the disease and reduce the subsequent side effects of it.
  • Keywords: Type 1 diabetes, cell therapy, mesenchymal stem cells, Beta cell , Personalized medicine