• Sever lung abnormalities in adult T leukemia/lymphoma patients, case reports and the effect of HTLV-1 infection on bronco-alveolar changes in female BALB/c mice
  • Mahdiyeh Hedayati Moghadam ,1,* S.A Rahim Rezaee ,2 Saeed Niazmand ,3 Mohammad,4
    1. Department of Physiology, School of Medicine, Jiroft University of Medical Sciences, Jiroft, Iran
    2. Immunology Research Center, Inflammation and Inflammatory Diseases Division, Mashhad University of Medical Sciences, Mashhad, Iran
    3. Department of Physiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
    4. Department of Physiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran


  • Introduction: Human T-cell leukemia virus type 1 (HTLV-1) infection is more likely induces non-neoplastic inflammatory pulmonary diseases. In 2017 three HTLV-1 patients who in their admission to the other hospitals treated for sever bronco-alveolar diseases, referred to the educational Ghaem Hospital (Mashhad- Iran), diagnosed with HTLV-1 associated malignancy (ATLL) and severe lung disease. Therefore, an experimental study was conducted in HTLV-1-infected BALB/c mice for remodeling of lung biomarkers
  • Methods: Twenty female BALB/c mice were divided into two groups comprising of control and HTLV-1-infected animals. The HTLV-1-infected group was inoculated with 106 MT-2 HTLV-1-infected cells. Two months later, firstly, the infection was confirmed using real time PCR and then lung pathological changes, the total and differential inflammatory cell counts in the blood and broncho-alveolar lavage fluid (BALF) along with oxidative stress biomarker levels in the BALF and lung tissue were evaluated
  • Results: In the HTLV-1-infected group only peribronchitis, total white blood cell (WBC), neutrophil, lymphocyte and monocyte counts in the blood and the BALF, eosinophil count in the blood, basophil count in the BALF and malondialdehyde in the lung tissue and the BALF significantly increased compared to the control group, while total thiol level and superoxide dismutase activity were decreased.
  • Conclusion: The HTLV-1 infection seems that can induce inflammatory reactions by recruiting inflammatory cells particularly, basophils and eosinophils and also, inducing oxidative stress in the pulmonary system
  • Keywords: HTLV-1, bronco-alveolar changes, BALB/c mice, oxidative stress