Introduction: Alzheimer’s disease (AD) is a devastating neurodegenerative disease accompanied by common emotional symptoms such as anxiety and fear. The bio-distribution and retention of lipid-based nanocarrier such as phytosome, increase due to their unique properties including nanoscale size, enhanced drug pharmacokinetic and pharmacodynamic profiles. The aim of this study was investigated Anxiolytic effects of sumac extract, conventional and phitosomal, by elevated plus maze test in Alzheimer rat.
Methods: five groups (saline-saline control, nanophytosome of Sumac-salin control, streptozotocin-saline, and streptozotocin with(40mg/kg) doses of sumac extract and nanophytosome - sumac of rats were examined. Afar 21 days, rat in all groups were subjected to elevated plus maze.
Results: Rat exposed to STZ, exhibited increased anxiety, Compared to controls, both the time spent in open arm and the total number of arm entries were significantly decrease in STZ rats during elevated plus-maze test (P<0.001). We found that STZ-induced anxiety like behavior. while, Treatment with sumac nanophytosome resulted in a significant increase in the time spent in the open arms and total number of arm entries (P<0.001).
Conclusion: previous Study findings showed anxiety in patients with AD, and treatments for anxiety might, therefore, be effective in reducing the psychiatric burden of AD. Through combining behavioral observations, our study reinforces that sumac Nano phytosome exhibited the strongest anti-anxiety properties.
Keywords: sumac nanophytosome; anxiety- like behavior; Alzheimer; rat