مقالات پذیرفته شده در سومین کنگره بین المللی زیست پزشکی
The Therapeutic Effects of Probiotics on Obesity and Weight loss
The Therapeutic Effects of Probiotics on Obesity and Weight loss
mohammad saeedi,1,*Shaghayegh Omidi,2
1. Semnan University of Medical Sciences and Health Services 2. Semnan University of Medical Sciences and Health Services
Introduction: Obesity is a medical condition in which surplus body fat accumulates. Excessive agglomeration of adipose tissue can decrease health indicators such as a decrease in average life expectancy or a decrease in quality of life. Obesity is caused by a variety of causes, including food intake, physical inactivity, and genetic aptitude and obesity can be caused by medications and endocrine/mental disorders. Probiotics are bacteria that have different strains, such as Enterococcus faecium (E. faecium), Bifidobacterium breve (B. breve), Streptococcus thermophilus (S. thermophilus) and Lactobacillus gasseri (L. gasseri) that can have beneficial effects on human health and can also be used as a supplementary therapeutic agent for metabolic disorders such as obesity, hypertension and so on. The aim of this study was to investigate the probiotic strains and their effect on obesity and weight loss.
Methods: In this review, the indispensable information collected through various articles by systematic review and search in websites such as the Pub Med and Google Scholar. About 15 articles published from 2015 to 2019 were reviewed and the results of these studies were procured.
Results: Recent studies have shown that the function of probiotics can include short-chain fatty acids (SCFAs) production, Resistance to bile salts and enzymes, reduced body mass index (BMI), weight loss and improved lipid profile. By studying various articles, we point out some of the results of these articles that probiotics can have a therapeutic role in obesity, for example, some species of probiotics such as L. gasseri decrease BMI, waist, abdominal visceral fat area (VFA) and hip perimeter, this probiotic bacterium in adults with large VFA can lessen BMI and arterial blood pressure (BP) values. E. faecium and S. thermophilus in overweight people can cause weight loss, systolic BP, low-density lipoprotein cholesterol (LDL-C) and elevated fibrinogen levels. L. acidophilus, B. lactis and L. casei change the gene expression in peripheral blood mononuclear cell (PBMCs) also BMI, fat percentage and leptin levels, L. plantarum lessen BMI and arterial BP values, L. acidophilus, B. animalis subsp. lactis decrease fasting glucose concentration and increase homeostasis model assessment of insulin resistance (HOMA-IR), L. rhamnosus and inulin decrease leptin and increase in lachnospiraceae and L. salivarius increment the proportion of Bacteroides, Prevotellae, and Porphyromonas.
Conclusion: By reviewing the literature, it can be concluded that probiotics can have beneficial effects on human health and can also be effectively used as a supplement in the treatment of metabolic diseases such as obesity and weight loss.