Introduction: Abortion and infertility are the most common reproductive disorders in which hormonal changes are effective. Somatotropin (growth hormone) and prolactin hormones with a similar structure associated with sex steroid hormones have an effective role in reproduction and fetal growth. In this study, serum levels of growth hormone and prolactin were evaluated in three fertile, infertile, and repeated groups.
Methods: 50 samples selected for each group. Infertile women were pregnant with IVF and similar to fertile women and recurrent abortions under the age of twenty pregnancies. After blood collection, serum levels of growth hormone and prolactin measured by ELISA method. The data analyzed by SPSS software using One Way ANOVA and Unpaired t-test.
Results: The results showed that the serum level of prolactin in the abortion group was highest amount ( 66.81 ± 8.22 ng / ml) in comparison with infertile women with a history of abortion (18.96 ± 5.86 ng / ml) (P <0.001) also fertile group with a history of abortion (66.18 ± 8.22 ng / ml) (P <0.001).
The level of prolactin was also measured by infertile women without abortion (36.99 ± 9.49 ng/ml) and infertile women without abortion (19.49 ±3.63 ng/ml). The difference was no statistic meaningful.
There was no significant difference in the level of growth hormone infertile women with a history of abortion (0.77 ± 0.24 ng/ml) compared to infertile women with history of abortion (4.22 ± 0.2 ng/ml) However, there was a significant correlation with patients with recurrent abortion (0.46 ± 0.11 ng/ml) (p <0.001). The mean serum level of growth hormone in fertile and infertile individuals without abortion was 0.64 ± 0.1 ng/ml and (0.77 ± 0.4 ng/ml) respectively. There was no significant difference between them. However, the serum level of growth hormone was significantly different between fertile individuals without abortion and recurrent abortion (P <0.01).
Conclusion: The study showed that prolactin levels could predict the future of pregnancy in fertile women and women with multiple abortions. The process of increasing the level of the hormone prolactin and decreasing the level of growth hormone can disrupt the pregnancy process
Keywords: prolactin, somatotropin, recurrent abortion, fertility and infertility