• Antibiotic Resistance Patterns of Isolated Bacteria from Ventilator Associated Pneumonia (VAP) Cases by ESKAPE of Razavi Hospital, Mashhad
  • Rahelleh Hosseini,1,* Nazanin Ataee,2 Shahram Amini,3 Freshteh Shahriari,4 Lyla Lotfi,5
    1. Department of Biology, Kavian Higher Education Institute, Mashhad, Iran
    2. Department of Biology, Kavian Higher Education Institute, Mashhad, Iran
    3. Department of Anesthesia , Mashhad University of Medical sciences , Mashhad , Iran
    4. Laboratory, Razavi Hospital, Mashhad, Iran
    5. ICU, Razavi Hospital, Mashhad, Iran


  • Introduction: Ventilator-associated pneumonia (VAP) is the commoninfection in the intensive care unit (ICU)patients that increase morbidity and mortality rate hospital costs and the length of hospitalization. Most of the VAP-forming micro-organisms are resistant to the prevalent antibiotics.
  • Methods: ICU patients of Razavi Hospital have been screened and sampled for diagnosis of VAP during a one-year period (from March 2018 to March 2019). Based on microbiological tests, the frequency of germs and their antibiotic resistance were determined using disk diffusion methods. ICU patients of Razavi Hospital have been screened and sampled for diagnosis of VAP during a one-year period (from March 2018 to March 2019). Based on microbiological tests, the frequency of germs and their antibiotic resistance were determined using disk diffusion methods
  • Results: The results of this study show that the VAP incidence and the prevalence rate of antibiotic resistance in statistical population with VAP in Razavi Hospital of Mashhad areas the same as other hospitals high. In addition, there was also a high incidence of resistant infections in this hospital
  • Conclusion: During this period, among 4307 patients who were admitted to the ICUsof the Razavi Hospital, 142 patients with ventilation devices have suffered VAP infections after 48 hours.The most commonly detected offsets are included9.0% Enterococcus faecium, 12.5%Staphylococcus aureus, 21.8% Klebsiellapneumoniae, 33.0% Acinetobacterbaumanni, 21.8% Pseudomonas aeruginosa and 1.4%Enterobacterspp.Antibiotic resistance profiles include the following pattern:54 (38.0%) bacterial strains were MDR, 9 (6.4.0%) strains were MDR and possible XDR, and 51 (35.9%) MDR, Possible XDR and Possible PDR.
  • Keywords: Ventilator associated pneumonia (VAP), antibiotics, Resistance, ESKAPE