• engineering and reconstruction of eye tissue
  • misaghnouri,1,*
    1. biomedical engineering, Energy University


  • Introduction: the cornea consists of 3 cell layers and two membranes . now more than 10 million people worldwide are affected by corneal blindness. corneal lesions and disease can cause reversible distortions to the normal structure and physiology of the cornea , which often leads to corneal transplantation . however , donors are scarce and the risk of rejection is a concern at the moment . Although significant advances have been made in recent years , the wound healing scars are still complex and not fully understood . the tissue engineering and rehabilitation medicine is now in involved in the pursuit of new cornea therapies . this unique study examines the clinical and cellular aspects of corneal trauma and disease seamlessly , and provides a comprehensive view of the latest findings and potential therapies aimed at restoring corneal homostrionitis . provide corneal transplantation is the most successful organ transplant that is performed in humans.
  • Methods: within the framework of this review , in 2019, 14articles were used by pubmed and sciencedirect , the keywords of search engines used by google researchers .
  • Results: corneal regenerative medications have seen remarkable advances with technologies that are available from preautoappropriate therapies to clinical use . Reconstruction of the cornea using the environmental conditions of the human uterine cervical stem cells by TIMP-1and TIMP-2. TIMP-1 and TIMP-2 reduce the effects of corneal reconstruction by CM-hUCESC . CM-hUCESC rejuvenates the cornea and reduces corneal inflammatory protein cytokines in a dry eye rabbit model. Cm-hUCESC leads to proliferation and apoptosis in the corneal optical cells of the TIMP-1 and TIMP-2 mice.
  • Conclusion: there is a severe shortage of corneal donors , the only accepted treatment for corneal blindness , about 12.7 million people expect corneal transplants , but donated tissues can not meet this need alone . significant progress has been made in the reconstruction of the cornea by extending and introducing stem cells alone . or associated with scaffold biological materials such as fibroin silk . cellular scaffolds are based on the extracellular matrix (EMC) cornea for tissue growth . two main techniques are the creation of collagen based artifical implants or analogous peptides of EMC or decelularization allografts or xenografts . Another research class examines the development of biomaterial cell structure composites .
  • Keywords: corneal regeneration , eye tissue , stemcell