• Graphene oxide and osteogenesis
  • Saba Bagheri,1,* Reza Salarian,2 Farzane Jabari,3
    1. Biomedical Engineering Department, Maziar University, Royan 151, Iran
    2. Biomedical Engineering Department, Maziar University, Royan 151, Iran
    3. Biomedical Engineering Department, Materials and Energy Research Center (MERC), Alborz, Iran


  • Introduction: Osteogenesis is included one of the important properties in bone tissue engineering.In recent years,Graphene Oxide because of unique properties such as electrical conductivity,elasticity,protein absorption,and especially osteogenesis,... so much considered.Also GO supports attachment,proliferation and osteogenic differentiation of cells.
  • Methods: Studiess have shown that only scaffolds containing GO have antibacterial properties,but the rate of the cells has incresed significantly and the expression of specific bone tissue factors has increased.Of course the important point that should be considered is optimal dose of GO because it has a toxic effect on the bone marrow cells and causes a massive death of it.
  • Results: Researchers also find that GO can be blended with biocompatible polymers to create a antibacterial coating suitable for medical equipment that is prone to bacterial colonies(such as catheters).Surgical instruments covered with this substance ,for example can kill bacteria.This reduces the need for antibiotics and reduces postoperative infection and surgery recovery time
  • Conclusion: The addition of GO to tissue engineering scaffolds increases surface roughness and thus increases cell adhesion and improves the process of cell proliferation and migration and tissue regeneration rate.Surface roughness is one of the most important factors affecting cell-tissue interactions and changes in cellular behavior.Surface roughness increases cell proliferation and viability.Some researchers found that GO enhanced the ALP activity and GO improves poor mechanical property of resorbable scaffolds.By considering all the properties of GO,these materials have great potential to bone tissue engineering.
  • Keywords: Graphene Oxide, Tissue Regeneration, Cell Migration, Proliferation