Introduction: Brain tumors are malignant, heterogeneous and invasive, and mortality rates from these tumors are very high. Although there are several therapies for treating tumors such as surgery, radiation therapy, chemotherapy and immunotherapy for these patients, most of these treatments often have different qualities and there is a degree of disease return. The main challenge in the treatment of such tumors is the presence of a blood-brain barrier (BBB) that actively filters the molecules that enter the bloodstream.
Methods: In the context of this overview, 21 articles were used between the years 2000 through the end of 2018 using the keywords of PubMed, Google scholar search engines.
Results: One of the most important methods of drug therapy is the use of nano-scale systems. Optimizing a wide range of physico-chemical properties is one of the benefits of Nano scale drug delivery systems, which can solve several problems in the treatment of brain tumors. For example, gold nanoparticles can be used as radio sensors to increase the effect of radiation, while magnetic nanoparticles can be diverted through an external magnet.
Conclusion: one of the most important limitation of nanoparticles is
the creation of a structure called corona when nanoparticles enter the bloodstream due to the non-specific interactions between nanoparticle coatings and proteins that circulate in the bloodstream. Removing the nano particles from the circulation system is done by reticuloendothelial system. The most common methods used to escape the reticuloendothelial system are the covering the surface of the nanoparticles with hydrophilic surfactants and the using the particle white the size less than 80nm.
Keywords: brain tumor, nano particle, drug delivery