• Bone Regeneration of Magnesium Phosphate Cements
  • poone.kalvani,1 Farzane.Jabari,2,*
    1. Biomedical engineering, Maziar University, Noor, Mazandaran, Iran.
    2. Ph.D candidate of biomedical engineering (biomaterial), Materials and Energy Research Center (MERC), Alborz, IRAN


  • Introduction: This cements is highly sought due to the presence of phosphate compounds for hard tissue regeneration. Many studies have shown that the attachment and proliferation of osteoblast cells to magnesium-coated structures is far superior to the uncoated structure, resulting in faster bone repair. By considering all of these studies, the addition of magnesium to calcium phosphate cements may also improve the bone tissue regeneration rate.
  • Methods: In the context of this overview, 13 articles were used between the years 2000 through the end of 2018 using the keywords of PubMed, Google scholar search engines.
  • Results: While CPCs have antibiotics such as vancomycin added to the cement formulation, some MPCs may be naturally antibiotic. MPCs consistently show higher ingrowth of new bone than CPCs. The adhesive capabilities of MPCs, which are not inherent to CPCs, can be extremely useful for simple or compound fracture manipulation. These situations, as well as many others, require an injectable formulation. However the injectability of MPCs, inherent or additive-induced, has not been thoroughly explored.
  • Conclusion: Magnesium phosphate cements (MPC) provide more favorable clinical performances including shorter setting time, and higher resorption rates and strength, as compared to the commonly used calcium phosphate cements. These features make magnesium cements great potential candidates for orthopedic and dental applications. The results of cellular studies showed that cement containing magnesium can increase the differentiation and proliferation rates of cells, which would accelerate the process of regeneration.
  • Keywords: Magnesium phosphate cement, Bone tissue