1. Islamic azad university of Tehran north branch 2. Islamic azad university of Tehran north branch 3. Islamic azad university of Tehran north branch
Abstract
Introduction
In this work, we synthesized the novel composites based on mesoporous silica nanoparticles (msn) to use in photodynamic therapy (pdt). this composite included msn/ photosensitizer (ps), protoporphyrin ix (pp ix) and titanium oxide.
Methods
In the nanocomposite, ps/pp ix was covalently conjugated to a mesoporous silica network, and titanium oxide (with ability to stimulate ros optical production which cause damage to the cancerous cell) was coated onto the surface of composite by both coordination and electrostatic interaction. silica nanoparticles have been used to bind with the light- sensitizers from porphyrin family. silica-based nanomateriales have been developed as a substitute for the polymeric nanoparticles.
Results
These nanoparticles are resistant toward the microbial invasion, and their size, shape and the porosity can be easily controlled during the preparation process. in addition, the nanoparticles release their encapsulated compounds even in the unconventional ph and temperature conditions, therefore they can be used in pdt.
Conclusion
The mesoporous silica based composite possesses the good physicochemical properties can be applied as the suitable supports to carry the ps/ti-grafted pp ix as a good agent to damage the cell cancers via pdt method.
Keywords
Pdt, msn, photosensitizer (ps), protoporphyrin ix, cancer therapy
