The effect of low level laser in repairing diabetic wounds on animal and human models

Hamed Salehbarmi,1 Mahboubeh asgari,2,* Abdolrazagh barzegar,3 Mohamad anvari,4

1. Legal medicine research center, Legal medicine organization ,tehran, Iran.
2. Legal medicine research center, Legal medicine organization ,tehran, Iran.
3. Legal medicine research center, Legal medicine organization ,tehran, Iran
4. Amirkabir university of technology, department of biomedical engineering



Diabetes mellitus is one of the most common diseases in iran and the world. diabetic foot is one of the most common and debilitating complications of diabetic patients, with wound healing delayed and can lead to amputation. methods various ways have been introduced to accelerate the recovery of chronic diabetic foot, including the use of bioportical stimulation with low-level lasers. however, it is not clear yet what the microbial load of the wound (as a wound healing prognosis factor) is affected by the low-level laser. the aim of this study was to evaluate the low-level laser on diabetic ulcers and treatment on it.


Patients with diabetic wounds of 1 to 3 wagner were enrolled. after providing satisfaction, patients underwent debridement of the standard surgical treatment of antibiotics. the patients were randomly divided into two groups of laser and placebo and lysing with a wavelength of 635 nm with a dose of 2j / cm2. animal studies are used because of the relative ease of working with rodents in most animal model studies. studies have also been conducted on the effects of llt on the repair of diabetic ulcers and the survival of skin flaps, skin ulcers repair. in this method, 20 diabetic rats and grade 3 ulcer were evaluated in the laser and drug group.


Between and within groups, diameter, redness, and edema of the wounds were similar throughout the entire observation period. irradiation of the burns accelerate wound healing when compared with control wounds.


The initial phase of the study showed that the effect of the laser on the microscopic load or the rate of repair of the diabetic wound was only satisfactory with respect to the drug therapy, and additional studies were needed for further investigation.


Low-level laser, diabetic wound treatment, diabetic wound medication