1. Department of biotechnology Islamic Azad university of urmia,iran 2. Department of biology Islamic Azad university of urmia,iran
Epigenetics involves the study of heritable changes in the regulation of gene activity and expression that are not dependent on gene sequence. main mechanisms of epigenetic modifications are dna methylation, histone modification and nucleosome positioning. several studies have shown that these modifications are related to cancer initiation, progression or tumor metastasis. in contrast to genetic mutations, most epigenetic modifications may be reversible and preventable. therefore, the resetting of aberrant epigenetic states in neoplastic cells is an expanding therapeutic approach to treat or prevent cancer
The current study is a kind of review study in which the crucial data have been collected; in addition, keywords have been used systematically to search for related articles in reputable site
It is now clear that the disorders of epigenetic mechanisms can affect and compound with oncogenic mutation and cause to promote tumor growth. so, the management of aberrant epigenetic states as a way to target the formation and progression of cancer is a logical and effective therapeutic approach. an understanding of the link between epigenetic deregulation and cancer is applicable to prognosis as well as treatment.
It seems that many aspects of epigenetics are still unknown; moreover, various studies are ongoing to explore other epigenetic mechanisms, their relationship with each other as well as the development, and progression of various diseases especially cancer