Ketamine (2-chlorphenyl-2-methylamino-cyclohexanone),has been used to induce a schizophrenia-like condition as an animal model in which to study this condition. the observed an increase in oxidative damage marked by an increase in lipid peroxidation, and a decrease in enzymatic defenses, in the rodent brain is increased by administering ketamine in subanesthetic doses.
curcumin, a hydrophobic polyphenol, is the main material extracted from turmeric dried rhizomes. curcumin is a potent antioxidant and anti-inflammatory agent that has been known to have different drug effects. this bioflavonoid is a potent free radical scavenger that has the ability to inhibit lipid peroxidation in in vitro and invivo systems. the formulation of curcumin phytosomes (a collection of corcumins with phosphatidylcholine) is introduced to improve the bioavailability of curcumin.
the aim of this study was to investigate the effects of curcumin nano phytosome on malondialdehyde (mda) in sub cortex area of rats in an experimental model of schizophrenia induced by ketamine.
the rats were randomly divided to six groups of control, positive control, sham, ketamine, and two groups of ketamine receiving curcumin and curcumin nano phytosome at a concentration of 15 mg / kg body weight orally for 30 days. all groups received ketamine (20 mg / kg body weight) for intraperitoneal injection for 14 days except control and positive control. than lipid peroxidation as a measure of thiobarbituric acid reactive substances (tbars) formation was performed.quantitative data were analyzed by anova, tukey test at the level of p <0.05.
The findings of this study indicate that the curcumin and especially its nano phytosome decreased the mda in sub cortex area.
These results suggested that curcumin and especially its nano phytosome may inhibit ketamin-induced oxidative stress, and that it may possess therapeutic potential for the treatment of schizophrenia