1. Department of Biochemistry ,Pasteur Institute of Iran 2. Payam Noor University of Tehran East 3. Department of Biochemistry ,Pasteur Institute of Iran 4. Department of Biochemistry ,Pasteur Institute of Iran 5. Department of Biochemistry ,Pasteur Institute of Iran
Abstract
Introduction
Coronary artery disease is a leading cause of morbidity and mortality in the most of countries. traditional risk factor such as serum cholesterol ,blood pressure and smoking account for only 50% of cad mortality. there is strong evidence that oxidative free radical have a role in the development of degenerative disease including cad. oxidative free radical increase the peroxidation of low density lipoprotein(ldl) thereby increasing its uptake by macrophage with increased foam cell formation and atherosclerosis,thugh other mechanism may exist.lack of trace elements resulting in enhanced levels of oxidative stress of the human body . the aim of the present study was to investigate the association between serum levels of copper and zinc in patients with coronary artery disease and healthy subjects.
Methods
This study included 40 patients having angiographically demostrated cad attending cardiology ward of modaress hospital and 30 healthy subjects. serum was obtained by centrifugation at 3000 rpm for 10 minumtes and stored at -20 °c until assayed. serum concentration of zinc and copper were determined by atomic absorption spectrophotometer .
Results
Serum cu mean concentrations were 3.87 mg/l and 1.1 mg/l in patients and healthy subjects respectively. serum zinc mean concentrations were 1.08 mg/l and 1.5 mg/l in patients and healthy group respectively .serum zn mean concentrations in patients (1.08) were lower than those determined for healthy controls(1.5)
Conclusion
Trace elements play an important role in different physiological and metabolic processes. some trace elements have been reported to be risk factors of cad. the results of our study showed that serum levels of zinc in cad patients were lower than healthy subjects whereas serum levels of copper were higher in cad patients levels compared with controls.
result in low concentrations of zinc and high concentrations of copper may be considered as a risk factors for cad patients.
