Alphainfluenza virus from orthomyxoviridae family causes important zoonotic diseases ranging from asymptomatic infection to severe, systemic disease with above 90% mortality. hpai viruses of h5n1 subtype have been considered as a major animal and public health threat. bacterial genes, express various proteins, affect host immune system and can be used as cross immunoprotective agents.
Alphainfluenza h5n1 subtype clade 2.3.1c and b.licheniformis genes and protein data obtained from ncbi. they have been analyzed and evaluated as point of protein interactions and immunity by bioinformatic analyzing, iedb and b cell assay.
This study shows pgsbcaae genes from b.licheniformis, it’s genes expression, gamma_dpga polypeptide stimulates the host innate immune system, b cells and causes cross protection against bacteria and alphainfluenza h5n1 subtype clade 2.3.1c.
Use of effective bacterial genes above their important role in treatment of bacterial diseases, they will be useful in prevention and producing new drugs and vaccine with low cost.