The effect of curcumin, zinc and n-acetylcysteine on the mmp9 expression
Narges Jalilian,
1,* Keyhan ghatre-samani,
2 Effat farrokhi,
3 Aliye tabatabaee,
4
1. Student's Research Committee, Shahrekord University of Medical Sciences, Shahrekord, Iran
2. Cellular and Molecular Research Center, Basic Health Science Institute, Shahrekord University of Medical Sciences
3. Cellular and Molecular Research Center, Basic Health Science Institute, Shahrekord University of Medical Sciences
4. Student's Research Committee, Shahrekord University of Medical Sciences, Shahrekord, Iran
Abstract
Introduction
Cardiovascular diseases (cvd) are mostly prevalent in the general population.matrix metalloprotease 9 (mmp9) is a matrixin, which belongs to the zinc-metalloproteinases family involved in the degradation of the extracellular matrix. it has been demonstrated that high expression of mmp9 is one of the adverse factors that can lead to cardiovascular diseases. mmp9’s expression increase under many pathological conditions, for example, injured arteries and diabetes. so we would like to gain the best ways to reduce mmp9 expression. several studies have shown that some antioxidants can reduce mmp9 expression
Methods
This review was written using science direct, pubmed and web of science databases for english articles. the search keywords were “mmp9”, “atherosclerosis” and “antioxidant”.
Results
Curcumin, zinc(zn) and n-acetylcysteine(nac) can reduce mmp9’s expression that lead to decreased cardiovascular complications
Conclusion
Zn has antioxidant and anti-inflammatory properties that suppresses inflammation and consequently suppresses mmp9 expression and we concluded that zn supplement can be an effective co-treatment for atherosclerosis.
nac is an antioxidant and anti-inflammatory agent. it can down-regulate the expression of mmp9, accompanied by inhibition of nfk-β (nuclear factor kappa-light-chain-enhancer of activated b cells) activation and reduced expression of rage(receptor for advanced glycation end products)
and therefor inhibited age (advanced glycated end products)-rage signaling pathway.
curcumin is known as an antioxidant and anti-inflammatory agent. previous studies show that curcumin can reduce the expression of antiapoptotic and metastatic genes through suppression of iκb kinase (ikk) and protein kinase b (pkb) activation that lead to downregulation of some interleukin (il)-6, cyclooxygenase 2 (cox-2) and mmp-9.
Keywords
“mmp9”, “atherosclerosis” and “antioxidant”.
