1. ِDepartment of Biology , Science and research Branch , Islamic Azad University , Tehran , Iran 2. Department of Biology , Science and research Branch , Islamic Azad University , Tehran , Iran 3. ِDepartment of Biology , Science and research Branch , Islamic Azad University , Tehran , Iran
Abstract
Introduction
The present study investigated the anxiolytic effects of sinapic acid on nmri mice behavior in the elevated plus-maze (epm) apparatus
Methods
Male nmri mice weighing 30-45 g were used in the experiment. animals were divided randomly into five groups: control group and sinapic acid groups (5, 10 and 20 mg/kg, i.p.) and diazepam (0.75 mg/kg). thirty minutes after administration, the number of open- and closed-arm entries, and the time spent in open of the epm were recorded.
Results
Our results showed that administration of sinapic acid (10 and 20 mg/kg, i.p.) and diazepam (0.75 mg/kg) significantly increased number of entries and time spent in open-arm of the epm, whereas sinapic acid and diazepam significantly decreased number of entries and time spent in closed-arm of the epm.
Conclusion
The results of the present experiment indicate that sinapic acid may have an anxiolytic profile in mice behavior in the epm test. further research is required to determine the mechanisms by which sinapic acid exerts an anxiolytic effect in mice.
