Omega-3 and its effects on colorectal cancer

Mohammad hossein Montazeri,1,* Sima montazeri,2 Faeze shokri,3

1. Mazandaran University of medical science , faculty of medicine
3. Student research committee from Mazandaran University of medical science , faculty of medicine



Cancer as the second leading cause of death has always been a threat to human life and due to its peculiar nature and lack of a favorable treatment, it is considered as a research priority in all communities. gastrointestinal cancers are responsible for 15.5% of cancer deaths in iran. fish oil consumption has been shown to have a protective role in some chronic degenerative diseases. the health beneficial effects of fish oil have been attributed to the omega-3. several chemopreventive effects of omega-3 on cancer have been reported. nevertheless, the mechanisms of their anticancer roles have not been completely demonstrated. in this study, we attempted to introduce omega-3 and its effects on cancer. we described the mechanisms by which omega-3 is thought to have anticancer activity and also we reviewed published preclinical and clinical studies that support anti-coloretal cancer activities.


A comprehensive literature search was performed in pubmed, scopus, science direct and google scholar to identify primary research reporting the effects of omega-3, through october 2016. finally, we combined the results of previous investigations and carried out with sensitivity analyses on them.


Several articles and studies have proposed omega-3 pufas have chemopreventive effects on many cancers. likewise, several effects of omega-3 such as anti-inflammatory and anti-angiogenic recognized.


Our study represents consumption of omega-3 supplements can be effective in ameliorate colorectal cancer and preventing getting infected. thus, it would be probably an appropriate alternative to many chemical drugs. more research is recommended for this aim.


Omega-3, cancer, colorectal, anti-inflammatory