Evaluation of uricacid ,total antioxidant capacity (tac) in smoker s blood compared to non-smokers

Shokooh Nazi aval,1,* Amir hossein esmaeli,2

1. Department of Medical Science, Babol Branch, Islamic Azad University, Babol, Iran
2. Department of Medical Science, Babol Branch, Islamic Azad University, Babol, Iran



Smokers are exposed to significant amounts of oxidizing agents. most studies are about the effect of smoking on the oxidative damage phenomenon and antioxidant changes. oxidative stress plays an important role in the pathogenesis of many diseases, such as lung cancer, chronic diseases, pulmonary obstruction, respiratory distress and cardiovascular disease. they also contain a variety of different oxidant materials, such as free oxygen radicals, which are highly unstable, attacking macromolecules in the cell, including dna, proteins and cell membranes, and damage the cell. the present study was conducted to evaluate the concentration of uric acid, total antioxidant capacity in elderly smokers and compare it with non-smoker elderly people.


: in this analytical-comparative study, factors such as uric acid, total antioxidant capacity in smokers were studied. a total of 60 people were studied, 30 of them were healthy smoker drivers aged 45-70 years old and an average weight of 90-60 kg with a history of at least 10 cigarettes per day for at least 10 years and 30 non-smokers were randomly included in the study, and none of the subjects had cardiovascular disease, cancer, diabetes and infection, and people they were referred to the laboratory for screening and fasting blood samples from these people was taken. data were described as mean and standard deviation, and the mean of data was evaluated in two groups by independent t-test and spss software was used for statistical analysis. the significance level was considered as p <0.05.


Among the smokers and non-smokers, the parameters of total antioxidant capacity, uric acid were very significant at the statistical probability level of 1% (p <0.01) and the total od parameters at the level of 5% (0.05) > p) is meaningful.


Given the role of cigarette smoking as a risk factor for cardiovascular diseases and the role played by oxidative stress in them, measurement of uric acid in young smoker subjects represents a marker against tobacco-induced oxidative stress and recommends their timely giving up of smoking.


Cigarette men, total antioxidant capacity, uric acid