Synthesis, characterization and study of biological activities a novel cadmium(ii) complex of bipyridine derivatives
,1,* Niloufarakbarzadeh torbati
1. University of Sistan and Baluchestan
2. University of Sistan and Baluchestan
The cadmium(ii) complex of the formula [cd(5,5´-dmbipy)2(ac(2].2h2o (1), where 5,5´-dmbipy is 5,5´-dimethyl-2,2´-bipyridine and ac is acetate, was synthesized and characterized by ft-ir, uv–vis ,1hnmr spectroscopy, elemental analysis and single-crystal x-ray diffraction analysis. the antibacterial effects of complex (1) have also been examined in vitro against standard bacterial strains. the mic, mbc and inhibition zones of the complex 1 and its ligand (5,5´-dmbipy) and its metal salt (cd(ch3coo(2·2h2o) against the growth of microorganisms (one gram- positive standard strain of staphylococcus aureus, and one gram-negative standard strain of escherichia coli) are obtained.
A solution of cd(ch3coo(2·2h2o (0.04 g, 0.17 mmol) in h2o was added to solution of 5,5´dimethyl-2,2´bipyridine ligand (0.09 g, 0.51 mmol) that dissolved in methanol-h2o (1:1) (10 ml). the resulting solution was stirred for 3h at 50°c and left to slowly evaporate at room temperature. after 4 days, crystals of metal complex 1 were isolated. (mic) and (mbc) by the broth macrodilution assay in sterile test tubes, and the inhibition zones (iz) by the disk diffusion method. stock solution of the complex was prepared in distilled water and dmso. all the inoculated plates were incubated at 37°c for 24 h. this inhibition zone (iz) assay was performed three times and results averaged.
The mic, mbc and inhibition zones of the complex 1 and its ligand and its metal salt against the growth of microorganisms are obtained. cefazolin was used as negative control for gram negative antibacterial activity. the results show that complex 1 possesses antibacterial activity, and that this activity is higher than that of the free ligand. this conforms to the overtones concept and tweedy’s chelation theory.
The results of antibacterial show that complex 1 possess antibacterial activity, and that this activity is higher than that of the free ligand. comparison of the antimicrobial activities of the synthesized cadmium compound with similar complexes in the literature shows that our new compound are more strong.
Cd(ii) complex, 5,5´-dmbipy, spectroscopy, antibacterial effects