The long non-coding rnas; a new trend in molecular biology of infectious diseases
,1,* Sanaz jourghasemi
,2 Hamed manoochehry
,3 Sara khosravi
1. MSc student of Immunology, Students Research Committee, Hamadan University of Medical Sciences, Hamadan, Iran.
2. MSc student of Immunology, Students Research Committee, Hamadan University of Medical Sciences, Hamadan, Iran.
3. 2. Ph.D. student of medical biotechnology, Students Research Committee, Hamadan University of Medical Sciences, Hamada
4. MSc student of Microbiology, Students Research Committee, Hamadan University of Medical Sciences, Hamadan, Iran.
brucellosis is another example of infectious disease and one of the five most common zoonotic bacteria in the world (1). evidence suggests that non-coding rnas undoubtedly have an undeniable function in infectious disease, such as brucellosis. in these abnormalities, by use of replacement or inhibition of non-coding rnas is emerging as a new novel way in treatment. in this review, we focus on long non-coding rnas (lncrnas) that are involved in brucellosis (2). we define the long noncoding rnas and indicate a brucellosis-inclined list of lncrnas, and describe some of the role of lncrnas in infection (3), as well as current and future research programs for lncrnas for the treatment of infectious disease, especially brucellosis.
Pubmed, scopus, and google scholar were searched from january 2013 to may 2018. based on inclusion and exclusion criteria ten relevant experimental studies with moderate bias were selected. the effect of long non-coding rna new player in brucellosis was evaluated.
Our analysis showed that the presently available evidence confirmed the therapeutic potential of lncrnas in significantly inhibition and improvement of brucellosis symptoms.
Lncrnas are an emerging field of investigation as they are suggested to regulate key biological processes, including cellular proliferation and differentiation, and their aberrant expression is strongly associated with infectious disease (4). an improved understanding of the role of ncrnas in brucellosis would provide valuable information about key infection-promoting pathways and might be highly useful for diagnostic and prognostic assessments (3). this knowledge might also lead to advancement in the management of brucellosis through the development of novel personalized ncrna-based therapies.
Lncrnas, new marker, infectious disease, zoonotic bacteria, brucellosis