Adipose tissue derived mesanchymal stem cell conditioned media could attenuate brain inflammation in alzheimer model rats

Shima Mehrabadi,1,* Elahe motevaseli,2

1. Tehran university of medical science
2. Tehran university of medical science

Abstract


Introduction

In alzheimer's disease there is a extensive brain inflammation.studies showed that conditioned media derived from adipose tissue mesanchymal stem cell (ascm) has ant-inflammatory effects. for this reason we used it to attenuate inflammation in alzheimer model rats.

Methods

For induction alzheimer we used intrahyppocampal injection. then we injected i.p 0.2ml conditioned medium for 7 days in rats. in 7th day we extracted brain and made slice then measured tnf-a and il-1b as inflammatory factor via elisa

Results

We observed that in alzheimer model level of tnf-a and il-1b increased and in treatment group this factors decreased.

Conclusion

This study showed that ascm could reduce inflammation in alzheimer.

Keywords

Alzheimer