1. Tehran university of medical science 2. Tehran university of medical science
In alzheimer's disease there is a extensive brain inflammation.studies showed that conditioned media derived from adipose tissue mesanchymal stem cell (ascm) has ant-inflammatory effects. for this reason we used it to attenuate inflammation in alzheimer model rats.
For induction alzheimer we used intrahyppocampal injection. then we injected i.p 0.2ml conditioned medium for 7 days in rats. in 7th day we extracted brain and made slice then measured tnf-a and il-1b as inflammatory factor via elisa
We observed that in alzheimer model level of tnf-a and il-1b increased and in treatment group this factors decreased.
This study showed that ascm could reduce inflammation in alzheimer.