Mda-7/il-24: as an anti-cancer gene in human breast cancer

Pollet Bet benyamin,1,* Saman yasamineh,2

1. Undergraduate cellular and molecular Biology, Institute of Higher Education Rab-Rashid, Tabriz, Iran
2. Undergraduate Biotechnology, Institute of Higher Education Rab-Rashid, Tabriz, Iran



Breast cancer continues to be a leading cause of cancer-related deaths in women worldwide. wnt/β-catenin signaling is one of the key pathways that promote self-renewal of breast cancer-initiating/stem cells.breast cancer-initiating display high levels of expression of apoptotic regulating proteins including bcl-2, nf-κb and akt. mda-7/il24 is a secreted protein of the il-10 family, functions as a cytokine at normal physiological levels and located on chromosome 1q32-33 in humans and it can encodes a 206 amino acid protein. our recent study showed that mda-7/il-24 also inhibited the growth and self-renewal potential of breast cancer-initiating/stem cells without any adverse effects on normal breast stem cells.


In this review, we study characteristic of mda-7 by using the several article. these articles are acquired through searches on online database such google scholar and pubmed.


Mda-7/il-24 plays a prominent role in inhibiting tumor growth, invasion, metastasis.rational combination of agents that would synergize with mda-7/il-24 would help to overcome the resistance of cancer cells toward conventional treatment regimens as well as generate the biological response at low doses.additionally, novel strategies to define ways of selectively inducing mda-7/il-24 expression, protein production and secretion using small molecules would also augment the applications of this novel cytokine for therapy of cancer. accordingly, concerted research efforts in the context of mda-7/il-24 will not only augment our understanding in the related field of mechanisms of action.


In this article, we introduced mda-7/il-24 as one of the methods of gene therapy, which effect on immune cell for treatment of breast cancer.


Mda_7, gene therapy, breast cancer