1. Department of Biotechnology,Faculty of Advanced Sience and Technology, Tehran Medical Siences, Islamic Azad University , Tehran, Iran 2. Department of Biotechnology,Faculty of Advanced Sience and Technology, Tehran Medical Siences, Islamic Azad University , Tehran, Iran
Abstract
Introduction
Micrornas (mirnas) play key roles in regulating genes of the apoptosis that regulation of apoptosis is broken in cancers. tremendous efforts have been made to develop cancer biomarkers by detecting circulating extracellular mirnas directly released from tumors. lung cancer is a primary cause of cancer-related death. the aim of this study was to examine the expression mirna-503 and 26a in the lung cancer patients in comparison to health controls
Methods
We analyzed expression of 2 mirnas (mirs-26a and 503) in pbmcs of a training set of 40 individuals with non-small cell lung cancer (nsclc). this cross-sectional study was performed on 40 health controls as well as. expression of mir503, and 26a were evaluated using real-time pcr technique.
Results
Expression of mirna26a was significantly increased in non-small cell lung cancer patients comparison to health controls.
Conclusion
Lung cancer can ectopic expression mirna26a and it may be concluded that increased expression of mirnas
